5,122 research outputs found

    Statelessness and applications for leave to remain: a best practice guide

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    The UK Immigration Rules were amended in April 2013 to include a new category of leave: ‘Part 14 stateless persons’. Statelessness arises when a person is not a national of a state. The guide focuses upon the definition applied by the UK Immigration Rules: ‘a person who is not considered as a national by any State under the operation of its law’. This definition is taken from the 1954 Convention relating to the Status of Stateless Persons (the 1954 Convention). An important feature of the Immigration Rules relating to stateless persons is the scope they provide to secure recognition by the Home Office of statelessness, a legal condition which itself has important consequences in international law. The guide sets out the view of the authors on best practice in advising and representing clients considering or making an application for statelessness leave in the UK. The UK law in this area is in its infancy and is likely to develop particularly quickly. Some key questions of law and practice have yet to be addressed by the courts; the guide provides a snapshot of the state of play as at September 2016. It is aimed at those who may represent clients considering whether and when to make an application for leave to remain as a stateless person. It may also be of use to organisations working with potentially stateless persons who may refer them to legal advisers. It is a joint publication of the Immigration Law Practitioners' Association and the University of Liverpool. The authors are in-house solicitors in the Law Department's Law Clinic

    Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma

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    In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found. The skipping of these two exons results in 109 amino acids being deleted from the receptor. The truncated receptor was expressed in all tissues and cells examined, but the level of expression varied. In melanoma cell lines and melanoma tissues, the truncated receptor gene was the major species, whereas the wild-type ETA was predominant in other tissues. A 1.9-kb ETA transcript was identified in melanoma cell lines by Northern blot, which was much smaller than the transcript in heart and in other tissues reported previously (4.3 kb). The cDNA coding regions of the truncated and wild-type ETA receptors were stably transfected into Chinese hamster ovary (CHO) cells. The truncated ETA receptor-transfected CHO cells did not show binding affinity to endothelin 1 (ET-1) or endothelin 3 (ET-3). The function and biological significance of this truncated ETA receptor is not clear, but it may have regulatory roles for cell responses to ETs

    An exploration of predictors of children's nurses' attitudes, knowledge, confidence and clinical behavioural intentions towards children and young people who self-harm

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    Aims and objectives: To explore the potential predictors of children's nurses? attitudes, knowledge and confidence towards caring for children and young people admitted to hospital with self-harm. Background Admissions to paediatric inpatient settings for individuals who have self-harmed are growing. Limited previous research suggests that nurses have mixed attitudes towards people who have self-harmed and potentially lack the confidence to provide effective care. There is a specific paucity of research in this area for children's nurses. Design: A cross-sectional descriptive survey was used to gather data for exploration of variables associated with attitudes, confidence, knowledge and clinical behavioural intentions of 98 registered children's nurses in a single tertiary children's hospital, colocated in a large acute NHS Trust in the UK. Methods: Data were collected over a 4 weeks in 2015, using an online survey tool. The predictive effect of several demographic variables was tested on the outcomes of attitudes, knowledge, confidence and behavioural intentions, which were collected using relevant, previously used outcome measures. Results: Increased experience was found to be associated with improved attitudes relating to negativity. Previous training in caring for children who had self-harmed was found to be associated with improved attitudes around perceived effectiveness of their care. Higher academic qualifications and having undertaken previous training on self-harm were each found to be associated with increased knowledge of self-harm, and increased age was associated with reduced knowledge of self-harm. Conclusions: This study provides an initial exploration of variables associated with attitudes, knowledge, confidence and behaviour intentions of registered children's nurses in relation to caring for CYP who have self-harmed. Relevance to clinical practice: Targeted training on caring for CYP who have self-harmed should be considered as a component of continuing education for registered children's nurses in the UK to improve the experience and outcomes for this patient group

    Reference to index of the letters, estimate and quotation, wages analysis book, pay book and balance statements of Carter & Peace, building contractors and hardware merchants, Burnie, 1920

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    Carter & Peace, building contractors and hardware merchants were established in Burnie in 1920 by J.C. Peace and A.H. Carter. Mr Peace died in 1946 and Mr Carter in 1960, but the firm continued until1970 when the Peace estate was wound up and the managing director, A.H. McInnes, retired and was sold in 1971. The firm undertook building work through out the north west coast, including, for example: Devon Hospital (1924), N.W. Butter Factory, Ulverstone Picture Theatre (1926), Bay View Hotel (1927), Ulverstone State School (1927), Burnie Technical School (1946), S1. David's Church Cooee (?1931), Somerset Bacon Factory (?1936), Baptist Church Offices Launceston (1934), Burnie Star of The Sea Church side altars (?1939). The records cover the period 1920-1957 and include estimates books, which contain a detailed list of fittings and materials needed and are especially useful, correspondence and staff pay records. - Transfered to the Tasmanian Archives and Heritage Office (TAHO) - Jan 2013 -www.linc.tas.gov.au/tasmaniasheritage - Private Deposit C.1

    The technological and economic prospects for CO2 utilization and removal

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    The capture and use of carbon dioxide to create valuable products might lower the net costs of reducing emissions or removing carbon dioxide from the atmosphere. Here we review ten pathways for the utilization of carbon dioxide. Pathways that involve chemicals, fuels and microalgae might reduce emissions of carbon dioxide but have limited potential for its removal, whereas pathways that involve construction materials can both utilize and remove carbon dioxide. Land-based pathways can increase agricultural output and remove carbon dioxide. Our assessment suggests that each pathway could scale to over 0.5 gigatonnes of carbon dioxide utilization annually. However, barriers to implementation remain substantial and resource constraints prevent the simultaneous deployment of all pathways

    Multidrug resistant Kluyvera ascorbata septicemia in an adult patient: a case report

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    <p>Abstract</p> <p>Introduction</p> <p><it>Kluyvera ascorbata </it>has become increasingly significant due to its potential to cause a wide range of infections, as well as its ability to transfer gene encoding for CTX-M- type extended spectrum B-lactamases (ESBLs) to other Enterobacteriaceae.</p> <p>Case presentation</p> <p>We report the case of a 64-year-old African-American male diagnosed with severe sepsis due to a multidrug resistant <it>Kluyvera ascorbata</it>, which was isolated from his blood. He was treated with meropenem and had a favorable outcome.</p> <p>Conclusion</p> <p>To the best of our knowledge, this is the first case report of a multidrug resistant <it>Kluyvera ascorbata </it>isolated from the blood in an adult patient with sepsis.</p

    Transit Timing and Duration Variations for the Discovery and Characterization of Exoplanets

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    Transiting exoplanets in multi-planet systems have non-Keplerian orbits which can cause the times and durations of transits to vary. The theory and observations of transit timing variations (TTV) and transit duration variations (TDV) are reviewed. Since the last review, the Kepler spacecraft has detected several hundred perturbed planets. In a few cases, these data have been used to discover additional planets, similar to the historical discovery of Neptune in our own Solar System. However, the more impactful aspect of TTV and TDV studies has been characterization of planetary systems in which multiple planets transit. After addressing the equations of motion and parameter scalings, the main dynamical mechanisms for TTV and TDV are described, with citations to the observational literature for real examples. We describe parameter constraints, particularly the origin of the mass/eccentricity degeneracy and how it is overcome by the high-frequency component of the signal. On the observational side, derivation of timing precision and introduction to the timing diagram are given. Science results are reviewed, with an emphasis on mass measurements of transiting sub-Neptunes and super-Earths, from which bulk compositions may be inferred.Comment: Revised version. Invited review submitted to 'Handbook of Exoplanets,' Exoplanet Discovery Methods section, Springer Reference Works, Juan Antonio Belmonte and Hans Deeg, Eds. TeX and figures may be found at https://github.com/ericagol/TTV_revie

    e-Roster Policy: Insights and implications of codifying nurse scheduling

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    Following a decade of dissemination, particularly within the British National Health Service (NHS), electronic rostering systems were recently endorsed within the Carter Review. However, e-rostering necessitates the formal codification of the roster process. This research investigates that codification through the lens of the 'Roster Policy', a formal document specifying the rules and procedures used to prepare staff rosters. This study is based upon analysis of twenty-seven publicly available policies, each approved within a four-year period from January 2010 to July 2014. This research finds that, at an executive level, codified knowledge is used as a proxy for the common language and experience otherwise acquired on a ward through everyday interaction, while at ward level the nurse rostering problem continues to resist all efforts at simplification. Ultimately, it is imperative that executives recognise that e-rostering is not a silver-bullet and that information from such systems requires careful interpretation and circumspection
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